And that is pretty much everything, because the ego is quite adamant that you are totally empty and devoid of all-that-is and therefore MUST go off on a lonesome journey to try to REPLACE it.
And in that journey, you will attempt to replace it with things, stuff, artificial idols, false values, etc... which attempt to REPLACE what the ego says you lost.... i.e. replace it with something ELSE. You want something else instead of the real thing because you believe you CANNOT HAVE the real thing, so have to SETTLE for substitutes (unworthiness).
But this other 'stuff' that you try to replace God with, does not really satisfy you like God does. So you really continue to feel empty.
There are a lot of business people especially who are very much excited about the pursuit of money and riches or fame and fortune, who believe that they ACTUALLY WILL FIND and CAN ACQUIRE what it is they are lacking. Their sense of lack is so great, that they are profoundly COMPELLED to seek strongly. And with a passion.
And in so doing they may indeed seem to find a lot of success in business. But at some point, they may also find, that they have really not found a solution to the emptiness inside. They've tried to replace the need for God with a need for other stuff, thinking that to get other stuff fills the hole, but it doesn't work. There is still an emptiness. And this is why many people then eventually throw in the towel and realize that they need something more meaningful in their lives than shallow accumulation of wealth.
I know someone personally actually who was very successful in business and very driven and passionate about it, making a lot of money and having all the gifts of a wealthy life etc, and pretty much everyone assessed that he was not really a very spiritual person and seemed to be quite strongly egotistical... and then later in life he hit this very same realization that all of this 'stuff' wasn't getting rid of the empty void inside. He had some kind of breakdown/breakthrough and realized that all of that pursuit and seeking did not really 'work' and that he needed a deeper meaning. And so began his sudden 'flip' into the pursuit of spirituality and a deeper truth.
The problem is, once we realize that "the world holds nothing that I want" - ACIM - we might unfortunately flip into a continued ego activity of "seeking for the truth". The presence of the seeking is still strong, and the subject matter of the seeking has changed to trying to find meaning and truth, but it's still actually the intense seeking that is the problem itself. And as you seek, you may seem to find, or at least take steps closer to the truth. But to really find the truth, you have to get DONE WITH SEEKING.
You only sought in the first place due to the profound sense of emptiness and lack of God and separation from the awareness of His presence. So THAT has to be healed and undone. And then the truth will be revealed, that you do not need to seek for God at all because GOD IS HERE!